A new article published in Stat Pearls reported that adiposis dolorosa – also known as Dercum disease, Ander syndrome, morbus Dercum, adipose tissue rheumatism, adiposalgia, or lipomatosis dolorosa, is a rare disorder of multiple painful subcutaneous growths of adipose tissue. This disease is classified into four types: generalized diffuse; generalized nodular; localized nodular; and juxta-articular forms. The article described that the generalized diffuse type presents with widespread painful adipose tissue with no apparent lipomas. The generalized nodular type manifests as widespread, painful adipose tissue that is more painful in the vicinity of lipomas. In the localized nodular type, the pain is restricted to areas within and around lipomas. Whereas, the juxta-articular type presents as painful solitary adipose tissue near large joints. It was discussed that the diagnosis of adiposis dolorosa is based on clinical assessment and is a diagnosis of exclusion. The proposed criteria for the diagnosis includes chronic pain of the subcutaneous tissue for over 3 months in overweight or obese patient. It was stated that in this condition, pain is often disabling and resistant to treatment. The disease is associated with weakness and psychiatric symptoms such as depression. While other associated symptoms include fatty deposits, easy bruising, sleep disturbances, impaired memory, difficulty concentrating, anxiety, rapid heartbeat, shortness of breath, diabetes, bloating, constipation, fatigue, and joint pain.