The purpose of a new study published in the International Neurourology Journal was to characterize the course of treatment for non-monosymptomatic enuresis with overactive bladder (OAB) in a real clinical setting. This study entailed an analysis of data from 111 OAB patients with moderate to severe enuresis. Anticholinergic medication, with or without laxatives, was administered to these patients following standard urotherapy, for 1 month. Desmopressin was added if there was a partial response to OAB. Patients were followed every 3 months and the status of OAB and enuresis were evaluated. The findings revealed that after 12 months of treatment, 64% and 88% of the patients experienced partial responses in enuresis and OAB, respectively. While urgency improved more quickly than enuresis, supporting the need to address daytime symptoms before enuresis. Overall, 71% patients had fecal impaction on kidneys, ureters, and bladder radiography (KUB) and/or subjective constipation. Meanwhile, the combination of anticholinergics with either laxatives or desmopressin showed greater efficacy than anticholinergics alone. In addition, daytime incontinence and anticholinergics- only treatment were associated with a lack of complete response (CR) during 12 months of treatment. Hence, the results confirmed the validity of addressing OAB before treating enuresis and underscored the need to address fecal impaction. It was stated that patients should be counseled regarding the importance of a prolonged course of treatment; anticholinergics should be accompanied with either desmopressin or laxatives for better control of enuresis.