A study published recently in the Journal of Obstetrics and Gynaecology enrolled 127 women aged 18-50 years with bacterial vaginosis and compared the vaginal suppository of metronidazole with a vaginal suppository of herbal medicine combination of Tribulus terrestris, Myrtus commuis, Foeniculum vulgare and Tamarindus indica. There were 63 patients in metronidazole group and 64 in the herbal vaginal suppository group. Both the groups received the medications for 1 week. Symptoms including the amount and odor of discharge and cervical pain were assessed using a questionnaire. Cervical inflammation and Amsel criteria (pH of vaginal discharge, whiff test, presence of clue cells and Gram staining) were investigated at the beginning of the study and 14 days following treatment. The amount and odor of discharge, Amsel criteria, pelvic pain and cervical inflammation significantly decreased in both groups. There was no statistically significant difference between the groups with respect to any of the clinical symptoms or the laboratory assessments. The herbal medicine preparation was shown to have a therapeutic effect similar to metronidazole in bacterial vaginosis. The plants used in this herbal vaginal suppository have antimicrobial activities. It has been used for the treatment of bacterial vaginosis in folk medicine for many years. This study showed that the therapeutic effect of this herbal medication on bacterial vaginosis is similar to metronidazole.