The objective of a study published in the Journal of Paediatrics and Child Health was to determine the effectiveness of a high-dose oral protocol using polyethylene glycol with electrolytes (PEG + E) combined with sodium picosulphate (SP) in treating fecal impaction in children. In this retrospective study, 44 children between 2-17 years of age with acute/chronic fecal impaction were administered six to eight sachets of PEG + E on day-1, with decreasing doses on the subsequent 3 days. Subsequently, 15-20 SP drops were given to these children on days 2 and 3. On day-4, PEG + E was reduced to one sachet and SP to 10 drops as an ongoing maintenance dose. It was noted that children began defecating within 10-12 hours after the initiation of therapy, reaching a maximum volume of stool (four cups per day) on day-2 of the intervention. In addition, all patients were disimpacted successfully, there was no reported fecal soiling or complications. Thus, it was concluded that a high-dose oral protocol combining PEG + E sachets and SP drops could successfully and safely disimpact children with acute/chronic constipation. Thus, this protocol was useful in controlling fecal disimpaction in an outpatient setting and could prevent hospitalization of children due to fecal impaction.