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Thiazide diuretics have been widely used for the treatment of hypertension. Their efficacy and cost-effectiveness often makes them a first-line choice in treating hypertensive patients. However, their effectiveness in patients with chronic kidney disease (CKD), especially those with a glomerular filtration rate less than 30 ml/min/1.73 m2, has been of concern. Consequently, they were thought to be ineffective in patients with advanced CKD.
There have been stud
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