A new study published in the Turkish Journal of Medical Sciences compared various scoring systems with the objective of determining the best system for predicting prognosis of patients with a prior diagnosis of cirrhosis, who had been hospitalized for hepatic encephalopathy. This study enrolled 84 patients with known cirrhosis hospitalized in the internal medicine ICU of a hospital with the diagnosis of hepatic encephalopathy, according to the West Haven criteria. The etiology of hepatic encephalopathy was recorded for all patients and Acute Physiology and Chronic Health Evaluation II (APACHE II), chronic liver failure-sequential organ failure assessment (CLIF-SOFA), Model for End-stage Liver Disease (MELD), and Child-Turcotte-Pugh (CTP) scores were calculated within the first 24 hours. Outcomes of patients were recorded as either discharged or deceased. The findings showed that etiologies of encephalopathy were infection in 41.7%; variceal bleeding in 22.6%; constipation in 17.9%; consuming excessive protein in 9.5%; hypokalemia in 7.1%; and hepatocellular carcinoma in 1.2%. Additionally, nine patients had grade-1 encephalopathy, while 34 patients had grade-2; 27 patients had grade-3; and 14 patients had grade-4. Furthermore, area under the receiver operating characteristic curve (AUROC) values were 0.986, 0.974, 0.955, and 0.880 for CLIF-SOFA, APACHE II, CTP, and MELD scores, respectively. The results indicated that the best prognostic model of hepatic encephalopathy for ICU patients was CLIFSOFA, followed by APACHE II, CTP, and MELD scores.