A new study published in Pain Research and Treatment assessed the incidence of constipation, health related quality of life (HRQOL), and disability in opioid-induced constipation (OIC) patients. In this prospective cohort study, 694 adult chronic non-cancer pain (CNCP) patients consecutively admitted to four multidisciplinary pain clinics (MPC) were enrolled. Brief Pain Inventory (BPI) and Short version of Treatment Outcomes in Pain Survey (S-TOPS) were used to measure functional outcomes and HRQOL. OIC was assessed using Bowel Function Index (BFI). Patients were followed-up for 6 months. The results showed that OIC prevalence at baseline was 25.8%. At 6 months, OIC incidence was 24.8%. Female gender, opioid therapy, and interference pain score on BPI were identified as OIC independent predictors. While OIC patients presented higher disability and pain interference and severity scores, and reported less satisfaction with the outcome. The findings suggested that constipation is a common adverse event among opioid users with major functional and quality of life impairment. Therefore, the need for OIC adequate assessment and management was emphasized upon.