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Antihyperglycemic effect of hesperetin, a citrus flavonoid, extenuates hyperglycemia.

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eMediNexus    31 October 2017

A new study published in Biomedicine Pharmacotherapy investigated the antihyperglycemic antioxidant and antihyperlipidemic effects of hesperetin a citrus flavonoid. In this experiment experimental rats were injected with STZ intraperitoneally at a single dose of 45mg kg for the induction of diabetes mellitus. It was observed that STZ induced rats showed marked increase in plasma glucose level and notable reduction in the level of plasma insulin. While the supplementation with hesperetin 40mg kg b.w to these animals for 45 days established a considerable decline in plasma glucose and a significant improvement in plasma insulin and glycogen levels. Additionally the altered activities of hepatic glucose metabolic enzymes lipid profiles enzymic antioxidants and serum biomarkers of liver and kidney toxicity were restored to almost normal. Further the acquired outcome were compared with glibenclamide 1mg kg b.w a standard oral hypoglycemic drug. Hesperetin treatment was found to be efficient in protecting the normal histological manifestation of hepatic renal and insulin positive 946 cells in STZ induced rats. From the results it was inferred that administration of hesperetin attenuates hyperglycemia and dyslipidemia through ameliorating antioxidant competence in STZ induced experimental rats.

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