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Positive familial history for metabolic traits predisposes to early and more severe alcoholic cirrhosis.

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eMediNexus    26 September 2018

A new study published in Liver International explored the association of family history of metabolic traits with age at diagnosis, severity and complications of alcoholic cirrhosis. This cross-sectional study recruited all consecutive patients with alcoholic cirrhosis presenting to a tertiary care center. For these patients, family and personal history, demographic characteristics, medical history, anthropometric measurements, and laboratory data were recorded along with the amount and duration of alcohol consumption. It was noted that among 1,084 alcoholic cirrhotics (males, mean age 48.5±10.1 years), family history for metabolic traits was documented in 63.5% patients. These patients were younger at diagnosis, had an increased incidence of jaundice, ascites, variceal bleed, and hepatic encephalopathy with consequently higher Model of End-stage Liver Disease (MELD), and Child-Turcotte-Pugh (CTP) scores. These patients developed cirrhosis in spite of a shorter median duration and lesser amount of alcohol consumption. Whereas, patients with both family and personal history of metabolic traits had a 3.3 times higher risk of an early age at diagnosis, 13.2 times higher risk of progression to cirrhosis with lesser amount of alcohol consumption and 4.6 times higher risk with lesser duration of alcohol consumption. The findings indicated that positive family and personal history of metabolic traits predisposes to alcoholic cirrhosis with an earlier age at onset and more severity despite lesser exposure to alcohol.

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