A new study published in the Middle East Journal of Digestive Diseases evaluated epidemiological features related to irritable bowel syndrome (IBS). This study recruited 9,264 participants, wherein IBS was diagnosed using the Rome IV criteria. Here, individuals with IBS were compared with a control group. Overall, 1,067 individuals were diagnosed with IBS, among which 5.3% were diarrhea dominant (IBS-D), 35.6% were constipation dominant (IBS-C), whereas 59% did not have any of the two (IBS-U). Back pain or arthralgia, insomnia, depression, female sex, anxiety, and being married, were associated with higher rates of IBS. Additionally, IBS prevalence elicited a peak at the age of 41 years for both men and women. Although not statistically significant, opium use was also found to be a contributing factor to IBS. The findings provided clues towards the causality between IBS and some major diseases such as liver disease.