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Efficacy, tolerance and safety of polyethylene glycol plus electrolytes in children.

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eMediNexus    31 October 2017

A study published in Anales de Pediatria assessed the renal safety gastrointestinal tolerance and dose effectiveness of polyethylene glycol with electrolytes at 1 3 and 6 months in children with functional constipation. This study evaluated three groups of 30 healthy pediatric patients aged between 2 and 10 years who suffered functional constipation Rome III criteria with 1 3 and 6 months of treatment. These patients were prescribed a mean dose of 0.37g kg day titrated according to age weight and response. The control group comprised 90 healthy children without treatment. The results showed that the number of stools per week during treatment evidenced an increment post treatment. In addition there was a significant difference in the Bristol scale score 1.9 0.75 versus 4.9 1.1 . Moreover the values of sodium and urine osmolality were normal in all groups with no statistical difference when compared to control values. Furthermore NIRA near infrared reflectance analysis values as well as the hydrogen breath test median 7ppm were normal in all patients. Hence it was inferred that there were no adverse renal biochemical parameters or gastrointestinal disorders with this treatment in children while tolerance and efficacy were optimal. Thus it was stated that polyethylene glycol with electrolytes can be safely recommended for the treatment of functional constipation in children in the short and long term.

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