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Hyperglycemia and association with electrolyte abnormalities in pediatric transplant recipients.

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eMediNexus    31 October 2017

A new study published in the Nephrology Dialysis Transplantation aimed to precisely estimate post transplant incidence of hyperglycemia and diabetes in children receiving solid organ transplants. This cohort study was conducted on 451 pediatric solid organ transplant recipients to determine the incidence of hyperglycemia and diabetes and the association of cations electrolytes with both endpoints. The results showed that 14.8 of the children developed hyperglycemia and 6 progressed to diabetes at a median of 52 days from transplant. While multi organ recipients had a 9 fold and lung recipients had a 4.5 fold higher risk for hyperglycemia and diabetes respectively when compared to kidney transplant recipients. On the other hand both magnesium and potassium had modest or no association with the development of hyperglycemia and diabetes. Thus it was concluded that hyperglycemia and diabetes occur in 15 and 6 children respectively and develop early post transplant with lung or multi organ transplant recipients at the highest risk. Furthermore hypomagnesemia and hypokalemia do not impose a significantly greater risk for hyperglycemia or diabetes in children.

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