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Hyperuricemia in obese patients with pharmacologically treated essential hypertension.

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eMediNexus    01 November 2017

A new study published in the Wiadomosci Lekarskie evaluated the prevalence of hyperuricemia among patients with essential hypertension and obesity pharmacologically treated with combination therapy. This study enrolled 109 obese patients with a mean BMI of 34.6 3.5 kg m2. These patients were treated with at least two antihypertensive drugs. It was observed that the average systolic blood pressure and diastolic blood pressure were of 131 5.9 and 84.6 3.6 mmHg respectively the average uric acid level was 6.4 1.5 mg dl while the average level of insulin was 17.6 11.0 mU L. Hyperuricemia was found in 27.5 of the patients while uric acid level was significantly higher among men. Additionally a positive correlation was noted between the serum uric acid concentration of serum insulin age and BMI of patients. On the other hand there were no significant differences in the concentration of uric acid among patients receiving multiple antihypertensive agents. Hence it was concluded that the incidence of hyperuricemia demonstrated in this study indicates a fairly common prevalence of this phenomenon among a population of patients with hypertension. It was stated that individually adjusted multidrug antihypertensive therapy does not seem to affect significantly the concentration of uric acid further research were proposed to confirm this finding.

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