The purpose of a new study published in The Turkish Journal of Gastroenterology was to evaluate the relationship between irritable bowel syndrome (IBS) and plasma and tissue ghrelin levels. This study recruited 90 adults who had undergone a gastroscopy procedure in the past. Patients with IBS symptoms were evaluated according to the Roma III criteria. The healthy control group comprised patients with no IBS symptom and those who had undergone gastroscopy procedure for another reason. For all these patients, the plasma ghrelin level and tissue ghrelin level obtained by immunohistochemical examination of biopsy specimens from the gastric antrum and corpus were evaluated. The findings showed that the median value of the plasma ghrelin level was 3.29 (range: 1.2-12.7) in the diarrhea group (IBS-D), 1.49 (range: 0.82-7.08) in the constipation group (IBS-C), and 1.5 (range: 0.2-3.7) in the control group. Moreover, the plasma ghrelin levels between the groups were found to be significantly higher in IBS-D than in IBS-C and the control groups. On comparing antral mucosal gland biopsy outcomes among the groups, staining intensity score was found to be significantly high in the IBS-C when compared to the control group, whereas no significant difference was noted between IBS-D and control groups. The results indicated that the plasma ghrelin level in IBS-D and the staining intensity in the antral mucosal gland in IBS-C were significantly higher. Meanwhile, there was no difference between the groups in terms of ghrelin staining intensity in gastric corpus.