A new article published in Life Sciences discussed that irritable bowel syndrome (IBS) is a functional disorder of the gastrointestinal tract and is usually associated with chronic abdominal pain and altered bowel habits. The two spectra of this disease include constipation-predominant IBS (IBS-C) and diarrhea-predominant IBS (IBS-D). Although earlier IBS was thought to be an unexplained brain-gut disorder, in the recent past, various underlying causes suggesting primary gut disturbance have been identified. The authors reported that the initial management of IBS primarily includes the non-pharmacological measures such as dietary modifications, increasing physical activity, and psychological therapy. Meanwhile, pharmacological management is an adjunct to non-pharmacological management, and the drug is chosen based on the predominant symptom of bowel habit.