A study was performed with an aim of comparing clinical endocrine and metabolic response after 6 months of therapy with either myo inositol or D chiro inositol or placebo in 137 women with polycystic ovary syndrome. The results showed that both myo inositol and D chiro inositol therapies displayed great potential in improving the regularity of the menstrual cycle the Acne Score endocrine and metabolic parameters and insulin resistance in young overweight polycystic ovary syndrome patients. Thus these agents could be considered optimal options for managing patients with polycystic ovary syndrome.