The purpose of a recent study published in Clinical Infectious Diseases was to investigate travelers diarrhea (TD) experiences of travelers from developed countries who visit Thailand. This TD surveillance study was conducted at a hospital in Bangkok, Thailand, between 2012 and 2014. Here, enteropathogens were identified using conventional methods and the TaqMan array card (TAC), which uses real-time polymerase chain reaction for the simultaneous detection of multiple pathogens. Analyses to determine pathogen-disease and symptoms association were performed to elucidate the clinical relevance of each enteropathogen. The findings showed that TAC identified more pathogens per sample than conventional methods. Campylobacter spp. were most prevalent, followed by the diarrheagenic Escherichia coli and norovirus GII. In addition, these agents had significant pathogen-disease associations as well as high attributable fractions among diarrheal cases. A wide range of pathogen loads for Campylobacter spp. was associated with TD while heat-labile toxin enterotoxigenic Escherichia coli was associated with an increased pathogen load. Furthermore, a majority of the cases were associated with inflammatory diarrhea and Campylobacter spp. and Shigella spp. were associated with dysentery. Thus, it was concluded that a pan-molecular diagnostic method such as TAC produces quantifiable and comparable results of all tested pathogens and reduces variability associated with multiple conventional methods. This allows for a better determination of the clinical relevance of each diarrheal etiologic agent along with their geographical relevance.Specialty: MicrobiomeTags: Gastroenterology, Infectious Diseases