The purpose of a new study published in Sexually Transmitted Diseases was to understand the biological reasons, as to how some women resist infection during vaginal intercourse with a man infected with Neisseria gonorrhoeae.This study entailed an investigation of modifiable biological bases for infection resistance by comparing women in the same core-mixing group who did or did not become infected after sexual exposure. Overall, 61 female contacts of index men with gonorrhea were selected from January 2008 through May 2012. Exposure and sexual practices and histories, co-infections, physical signs on exam, patient symptom report, and menstrual history were recorded.The results showed that 62.3% of the exposed women developed cervical infections. Meanwhile, a vaginal pH 4.5 or higher at presentation to clinic was significantly associated with gonococcal infection in women who presented within one menstrual cycle (35 days). Additionally, in this group of women, there was a significant association between acquiring an N. gonorrhoeae cervical infection and sexual exposure during menstruation. In conclusion, it was proposed that modification of vaginal pH could be a novel strategy for reducing the risk of N. gonorrhoeae infections in women.