A new article published in the Journal of Fungi discussed that Candida species are among the commonest causes of vaginitis in healthy women of reproductive age. Vulvovaginal candidiasis (VVC) is characterized by vulvovaginal itching, redness and discharge. Candida albicans, a common genitourinary tract commensal, is a prominent specie and continues to be the most common fungal agent isolated from clinical samples of patients diagnosed with VVC. The authors reported that in the recent past, there has been a marked shift in the etiology of candidiasis with non-albicans Candida (NAC) species gaining prominence. NAC now accounts for about 10-45% of VVC cases in some studies; this poses certain treatment challenges and renders a slightly different clinical picture. It was stated that vaginitis caused by NAC is milder in presentation, often occurs in patients with underlying chronic medical conditions, and its symptoms tend to be more recurrent or chronic compared to C. albicans vaginitis. While C. glabrata is the most common cause of NAC-VVC, C. tropicalis, C. krusei, C. parapsilosis, and C. guilliermondii are the other commonly implicated species. However, treatment failure is common in NAC-VVC since some of these species are intrinsically resistant or show low susceptibilities to commonly used antifungal agents.