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Fructan, rather than gluten, induces symptoms in patients with self-reported non-celiac gluten sensitivity. In a study performed at Oslo University Hospital in Norway from October 2014 through May 2016, the subjects were randomized to groups placed on diets containing gluten (5.7 g), fructans (2.1 g), or placebo, concealed in muesli bars, for 7 days.
Mean scores for GSRS-IBS bloating were 9.3 ± 3.5, 11.6 ± 3.5, and 10.1 ± 3.7, respectively, during the gluten, fructan, and placebo challenges (P = .004). The overall GSRS-IBS score for participants consuming fructans was significantly higher than for participants consuming gluten (P = .049), as was the GSRS bloating score (P = .003). Thirteen participants had the highest overall GSRS-IBS score after consuming gluten, 24 had the highest score after consuming fructan, and 22 had the highest score after consuming placebo. Hence, fructans were found to induce symptoms in individuals with self-reported non-celiac gluten sensitivity, measured by the GSRS-IBS… (Gastroenterology. 2018 Feb;154(3):529-539.e2)
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