Patients with primary Sjogrens syndrome are at increased risk of cardiovascular morbidity, as per a meta-analysis of 14 studies, which included more than 65,000 patients. The risk was significantly increased for coronary morbidity, cerebrovascular morbidity, heart failure rate and thromboembolic morbidity with no statistically significant increased risk of cardiovascular mortality. These findings suggest that these patients should be screened for cardiovascular comorbidities and considered for preventive interventions, in a multidisciplinary approach with cardiologists.