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Effects of Renal Denervation on Insulin Sensitivity and Inflammatory Markers.

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eMediNexus    06 November 2017

A recent study published in the Journal of Diabetes Research investigated the effect of catheter based renal sympathetic denervation RDN on glucose metabolism inflammatory markers and blood pressure in nondiabetic patients with treatment resistant hypertension. This open labelled study recruited 8 subjects who were studied before and 6 months after RDN. The results showed that insulin sensitivity M value increased negligibly from 2.68 8201 8201 0.28 to 3.07 8201 8201 0.41. A notable inverse correlation between the increase in M value and body mass index BMI 6 months after RDN was found indicating beneficial effects on leaner subjects. Furthermore blood pressure decreased considerably however there were no changes in hormones inflammatory markers or endogenous glucose production. These findings suggested that RDN may improve insulin sensitivity in some patients with treatment resistant hypertension. It was stated that the confirmation of these indications of beneficial effects on leaner subjects awaits the outcome of larger randomized controlled studies.

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