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The US Preventive Services Task Force (USPSTF) has posted a Draft Research Plan for Colorectal Cancer screening on its website on Jan. 3, 2019. It is open for public comment till Jan. 30, 2019. The research plan includes a proposed analytic framework, key questions, study approach and a decision mode as a guide for the systematic review of the evidence by researchers. The three key questions reviewed are:
- What is the effectiveness or comparative effectiveness of screening programs in reducing colorectal cancer, mortality, or both?
- What is the accuracy of direct visualization, stool-based, or blood-based screening tests for detecting colorectal cancer, advanced adenomas, or adenomatous polyps based on size?
- What are the serious harms of the different screening tests?