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High-intensity breastfeeding improves insulin sensitivity during early postpartum.

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eMediNexus    22 January 2019

A new study published in Diabetes/Metabolism Research and Reviews investigated whether high‐intensity breastfeeding (HIB) reduces insulin resistance during early postpartum period in women with gestational diabetes (GDM), independent of the postpartum weight change (PWC). This multicenter prospective study included 222 Japanese women with GDM who underwent a 75-g oral glucose tolerance test (OGTT) during early postpartum. Here, plasma insulin was measured during OGTT to obtain a homeostasis model of assessment of insulin resistance (HOMA-IR). The association between postpartum HOMA-IR and the breastfeeding status was investigated. All women underwent OGTT at 7.9±2.3 weeks postpartum with a PWC of -7.8±3.4 kg. The results revealed that though the rate of abnormal glucose tolerance (prediabetes and diabetes) did not differ between the groups, the HOMA-IR in 166 HIB women was significantly lower than those in 56 non-HIB women. Moreover, the effect of the HIB was independently associated with lower HOMA-IR after adjusting for confounders including PMC. On subgroup analysis, this effect was only noted in the obese women (BMI ≥25). Hence, it was inferred that in obese Japanese women with GDM, HIB has a significant effect in reducing insulin resistance during early postpartum, independent of the postpartum weight loss.

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