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Dr M Balasubramanyam, Chennai 27 November 2018

Exercise and lifestyle modification is the key for preventing and managing noncommunicable diseases, including type 2 diabetes.
Then what prevents you to prevent diabetes? Humans exhibit diverse responses to exercise training in terms of improvements in insulin sensitivity, mitochondrial function, oxygen consumption and muscle function and strength.
Why do some people respond to exercise when others don’t? Is it related to individual’s molecular profile? Is there any biomarker to distinguish responders versus nonresponders to exercise?
New biology insights endorse that the answer is in “EXERKINES” – the so-called exercise factors – released from distinct organs in response to exercise and mediate the pro-metabolic, multi-systemic and anti-aging benefits.
Exerkines are defined as molecular signatures (miRNAs, mRNAs, proteins) that are directly secreted into the plasma and/or released in extracellular vesicles, including exosomes.
The right collaboration of exercise (ing) biologists and physicians is expected to result in ‘precision exercise or personalized exercise prescription’ for disease prevention as well as management.

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