Hepatitis C: Have we Found the Right Formula? |
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Hepatitis C: Have we Found the Right Formula?
Dr Paul J Thuluvath, Baltimore,  05 December 2018
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Limitations of pangenotypic drugs:Sofosbuvir + velpatasvir for 12 weeks (contraindicated when GFR < 30 ml)Glecaprevir + pibrentasvir for 8-12 weeks (safe in renal failure and dialysis, but unsafe in child B and child C cirrhosis)Sofosbuvir + velpatasvir + voxilaprevir for 12 weeks (For DAA failures, contraindicated with GFR < 30 ml)National guidelines in India in:Treatment naïve HCV without cirrhosis: Sofosbuvir (400 mg) + daclatasvir (60 mg) for 12 weeksTreatment naïve HCV with ...
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