EXPLORE!

Newer Treatment Strategies for Treatment of Hepatic Encephalopathy in ACLF

  753 Views

Dr RK Dhiman    05 December 2018

  • HE with all grades of severity and independent of other organ failures is associated with increased mortality; the mortality is higher in grade 3-4 compared with grade 1-2 HE.
  • Inflammation plays a greater role in the pathogenesis of HE in patients with ACLF than in patients without ACLF and is associated with cytokine storm.
  • Ammonia is a simple surrogate marker for HE in ACLF and correlates with severity of HE/cerebral failure.
  • Ammonia levels at baseline > 144 mmol/l predicts mortality.
  • Management of HE in hospitalized patients requires admission to the ICU and includes identification and treatment of precipitating factors, including infections; and specific measures for decreasing hyperammonemia and systemic inflammation.
  • Large volume plasmapheresis or albumin dialysis and identification and embolization of portosystemic shunts may be required in refractory patients.

To comment on this article,
create a free account.

Sign Up to instantly get access to 10000+ Articles & 1000+ Cases

Already registered?

Login Now

Most Popular Articles

News and Updates

eMediNexus provides latest updates on medical news, medical case studies from India. In-depth medical case studies and research designed for doctors and healthcare professionals.